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 Dr. Tebbutt earned his B.A. (Hons.) in biochemistry from the University of Oxford (Oriel College), England in 1989, and his Ph.D. studying molecular genetics at the Cambridge Laboratory, John Innes Centre, University of East Anglia, England in 1993 (supervised by Dr. David Lonsdale). He undertook postdoctoral training in the laboratories of Professor Ann Harris (University of Oxford, Institute of Molecular Medicine) and Professor Diana Hill (University of Otago, Dunedin, New Zealand), where he studied the molecular genetics of cystic fibrosis. He was appointed Research Fellow at the University of Otago (1995-2001) and was seconded to a start-up biotechnology company (Global Technologies (NZ) Ltd.) as Director of Genomics (2000-2001). He moved to Canada in 2001, and was Senior Researcher in the Centre for Biomedical Research (University of Victoria, 2001-2002), prior to coming to the iCAPTURE Centre at St. Paul’s Hospital, Vancouver.
Dr. Tebbutt’s research interests include the genetics of complex respiratory disease and the development of robust technologies to assist in rapid genomic-based diagnostics. He also leads a multidisciplinary collaboration to investigate genomic interactions between fungal spores and human airway cells. Grateful acknowledgement for grant funding goes to the National Sanitarium Association, the British Columbia Lung Association, AllerGen NCE Inc. (Allergy, Genes and Environment Network), and the Canadian Institutes of Health Research (CIHR).
Education / Training:
University of Oxford, England: B.A. (Hons.) – Biochemistry,
1985-1989
University of East Anglia, England: PhD - Pollen-Specific Gene Expression,
1989-1993
University of Oxford, England: Postdoctoral studies – Paediatric
Molecular Genetics, 1993-1994
University of Otago, New Zealand: Postdoctoral studies – Dept.
Biochemistry, 1994-1995
Publications:
• Refereed
Journal Publications
Tebbutt, S.J. and Lonsdale, D.M. Identification of a defective transposable element in tobacco. Plant Molecular Biology 23(2):397-400 (1993).
Tebbutt, S.J., Rogers, H.J. and Lonsdale, D.M. Characterization of a tobacco gene encoding a pollen-specific polygalacturonase. Plant Molecular Biology 25(2):283‑297 (1994).
Tebbutt, S.J., Wardle, C.J.C., Hill, D.F. and Harris, A. Molecular analysis of the ovine CFTR gene. Proceedings of the National Academy of Sciences, USA 92:2293-2297 (1995).
Tebbutt, S.J. and Lonsdale, D.M. Deletion analysis of a tobacco pollen-specific polygalacturonase promoter. Sex. Plant Reprod. 8:242-246 (1995).
Lonsdale, D.M., Allen, R.L., Belostotsky, D., Ghose, T.K., Harvey, A.J., Rogers, H.J., Tebbutt, S.J. and Trick, M. An analysis of the relative activities of a number of promoter constructs from genes which are expressed during late pollen development as determined by particle bombardment. Plant Cell Reports 15:154-158 (1995).
Tebbutt, S.J., Broom, M.F., van Stijn, T.C., Montgomery, G.W. and Hill, D.F. Genetic and physical mapping of the ovine cystic fibrosis gene. Cytogenetics and Cell Genetics 74:245-247 (1996).
Tebbutt, S.J., Harris, A. and Hill, D.F. An ovine CFTR variant as a putative cystic fibrosis-causing mutation. Journal of Medical Genetics 33:623-624 (1996).
Hyde, K., Reid, C.J., Tebbutt, S.J., Weide, L., Hollingsworth, M.A. and Harris, A. The cystic fibrosis transmembrane conductance regulator as a marker of human pancreatic duct development. Gastroenterology 113:914-919 (1997).
Tebbutt, S.J., Lakeman, M.B., Wilson-Wheeler, J.C and Hill, D.F. Genetic variation within the ovine cystic fibrosis transmembrane conductance regulator gene. Mutation Research Genomics 382 (3/4):93-98 (1998).
Tebbutt, S.J., Stewart, R.E. and Hill, D.F. Isolation and characterization of DNA from whale bone. Journal of the Royal Society of New Zealand 30 (4):365-371 (2000).
Mouchel, N., Tebbutt, S.J., Broackes-Carter, F.C., Sahota, V., Summerfield, T., Gregory, D. and Harris, A. The sheep genome contributes to localization of control elements in a human gene with complex regulatory mechanisms. Genomics 76 (1-3):9-13 (2001).
Tebbutt, S.J. and Simons, C. Gene sequences from New Zealand's extinct huia. Journal of the Royal Society of New Zealand 32 (2):327-335 (2002).
Tebbutt SJ, Burkett KM, He J-Q, Ruan J, Opushnyev IV, Tripp BW, Zeznik JA, Abara CO, Nelson CC, Walley KR. A microarray genotyping resource to determine population stratification in genetic association studies of complex disease. BioTechniques 37:977-985 (2004).
Tebbutt SJ, Opushnyev IV, Tripp BW, Kassamali A, Andersen M. SNP Chart: an integrated platform for visualization and interpretation of microarray genotyping data. Bioinformatics 21:124-127(2005).
Tebbutt SJ, Mercer GD, Do R, Tripp BW, Wong AWM, Ruan J. Deoxynucleotides can replace dideoxynucleotides in minisequencing by arrayed primer extension. BioTechniques 40:331-338 (2006).
Walley DC, Tripp BW, Song YC, Walley KR, Tebbutt SJ. MACGT: multi-dimensional automated clustering genotyping tool for analysis of microarray-based mini-sequencing data. Bioinformatics 22:1147-1149 (2006).
Podder M, Welch WJ, Zamar RH, Tebbutt SJ. Dynamic variable selection in SNP genotype autocalling from APEX microarray data. BMC Bioinformatics 7:521 (2006).
Song YC, Kawas E, Good BM, Wilkinson MD, Tebbutt SJ. DataBiNS: a BioMoby-based data-mining workflow for biological pathways and non-synonymous SNPs. Bioinformatics 23:780-782 (2007).
Tebbutt SJ, James A, Paré, PD. Single nucleotide polymorphisms and lung disease - clinical implications. Chest 131(4):1216-1223 (2007).
Tebbutt, S.J. Genotyping of Single Nucleotide Polymorphisms by Arrayed Primer Extension Methods. Mol Biol;382:149-61 (2007).
Podder M, Ruan J, Tripp BM, Chu ZE, Tebbutt SJ. Robust SNP genotyping by multiplex PCR and arrayed primer extension. BMC Medical Genomics 1:5 (2008).
Chun Chan F, Kawas EA, Wilkinson MD, Tebbutt SJ. DataBiNS-Viz: a web-based tool for visualization of non-synonymous SNP data. Journal of Proteomics and Bioinformatics 1, 233-236 (2008).
Tebbutt SJ, Ruan J. Combining multiple PCR primer pairs for each amplicon can improve SNP genotyping accuracy by reducing allelic drop-out. BioTechniques 45:637-646 (2 (2008).
• Refereed Conference Proceedings
Slatter T, Azarian SM, Tebbutt SJ, Maw M, Williams DS. Screen for Usher syndrome 1B mutations in the ovine myosin VIIa gene. Adv.Exp.Med.Biol. 533:151-155 (2003).
Abbaspour M, Abu-Gharbieh, R, Podder M, Tebbutt SJ. Fully-automated analysis of multi-resolution four-channel microarray genotyping data. SPIE Medical Imaging (The International Society for Optical Engineering), San Diego-USA, 6144:61443M1-M3 (2006).
Abbaspour M, Abu-Gharbieh, R, Podder M, Tripp BW, Tebbutt SJ. Hybrid spot segmentation in four-channel microarray genotyping image data. ISSPIT (The 6th IEEE International Symposium on Signal Processing and Information Technology), Vancouver, Canada. M21.3 (2006).
• Invited Reviews
Tebbutt, S.J. Animal studies of cystic fibrosis. Molecular Medicine Today 1:336-342 (1995).
Tebbutt, S.J. Cystic fibrosis resources on the World Wide Web. Molecular Medicine Today 2:148-149 (1996).
Tebbutt, S.J. The development of a sheep model for cystic fibrosis. New Zealand BioScience 6: 10-16 (1998).
Tebbutt, S.J. Technology evaluation: AAV-CFTR vector, Targeted Genetics. Current Opinion in Molecular Therapeutics 1(4):524-529 (1999).
5. Tebbutt, S.J. Technology evaluation: Transgenic a-1-antitrypsin (AAT), PPL Therapeutics. Current Opinion in Molecular Therapeutics 2(2):199-204 (2000).
• Book Chapters
He, J.Q., Tebbutt, S.J. and Paré, P.D. Genetics of COPD. In: Barnes, P.J. and Hansel, T.T., editors. Recent Advances in Pathophysiology of COPD. pp. 1-20. Birkhäuser Publishing, Basel, Switzerland (2004).
Tebbutt, S.J., Sandford, A.J. and Paré, P.D. Genetics of Respiratory Disease. In: Hamid, Q., Shannon, J. and Martin, J.G., editors. Physiologic Basis of Respiratory Disease. pp. 349-362. BC Decker Inc., Ontario, Canada (2005).
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